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Article

Upf1 and Upf2 proteins mediate normal yeast mRNA degradation when translation initiation is limited.

Nucleic acids research - 15 May 1998

Barnes C A

Abstract excerpt

mRNA degradation is coupled with the process of mRNA translation. For example, an mRNA molecule, on which translation is prematurely terminated because of a nonsense codon, may be rapidly degraded. This nonsense-mediated mRNA decay in the yeast Saccharomyces cerevisiae is mediated by the Upf1 and Upf2 proteins. Yeast mRNAs can also be selectively destabilized by limiting the rate of translation initiation. Two...

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Identifiers

PMID: 9580697
DOI: 10.1093/nar/26.10.2433
PMCID: PMC147546

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