Discover Community Create You

Loading publication...

Noodle always counts identifier-free feature events for service operation. With your permission, Google Analytics can also estimate audience and engagement. Search text, publication identifiers, cookies, IP addresses and browser fingerprints are never included in Noodle's first-party event counters.

Privacy details

Article

The Human Acid-Sensing Ion Channel ASIC1a: Evidence for a Homotetrameric Assembly State at the Cell Surface.

PloS one - 1 Jan 2015

van Bemmelen Miguel Xavier, Huser Delphine, Gautschi Ivan, Schild Laurent

Abstract excerpt

The chicken acid-sensing ion channel ASIC1 has been crystallized as a homotrimer. We address here the oligomeric state of the functional ASIC1 in situ at the cell surface. The oligomeric states of functional ASIC1a and mutants with additional cysteines introduced in the extracellular pore vestibule were resolved on SDS-PAGE. The functional ASIC1 complexes were stabilized at the cell surface of Xenopus laevis...

Read the complete abstract on PubMed

Topics

Share this publication in a Topic to start or enrich a Post.

Share to Acid Sensing Ion Channels
Share to CHO Cells
Share to Cricetulus

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Share to Cross-Linking Reagents

Share to Cysteine

Share to Oocytes

Share to Protein Multimerization

Share to Xenopus laevis

Source

Open in PubMed Open full text

Identifiers

PMID: 26252376
DOI: 10.1371/journal.pone.0135191
PMCID: PMC4529235

Genes

ASIC1
SDS

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

Related research

Semantic proximity does not establish scientific evidence.

Research trail→

Click a neighbor to travelStep 1 · 12 closest

The Human Acid-Sensing Ion Channel ASIC1a: Evidence for a Homotetrameric Assembly State at the Cell Surface.PMID 26252376Read ↗

High-throughput characterization of photocrosslinker-bearing ion channel variants to map residues critical for function and pharmacologySemantic proximity Read ↗

Conformational plasticity of human acid-sensing ion channel 1aSemantic proximity Read ↗

Oxidant regulated inter-subunit disulfide bond formation between ASIC1a subunits.Semantic proximity Read ↗

Human ASIC1a mediates stronger acid-induced responses as compared with mouse ASIC1a.Semantic proximity Read ↗

Gating transitions in the palm domain of ASIC1a.Semantic proximity Read ↗

Mutation of a conserved Gln residue does not abolish desensitization of acid-sensing ion channel 1Semantic proximity Read ↗

Structural basis for amino acid exchange by a human heteromeric amino acid transporterSemantic proximity Read ↗

Molecular mechanism and structural basis of small-molecule modulation of the gating of acid-sensing ion channel 1.Semantic proximity Read ↗

Mutation of a conserved glutamine residue does not abolish desensitization of acid-sensing ion channel 1.Semantic proximity Read ↗

Ca <sup>2+</sup> -mediated higher-order assembly of b <sup>0,+</sup> AT–rBAT is a key step for system b <sup>0,+</sup> biogenesis and cystinuriaSemantic proximity Read ↗

Dynamic conformational changes of acid-sensing ion channels in different desensitizing conditionsSemantic proximity Read ↗

Molecular determinants of ASIC1 modulation by divalent cations.Semantic proximity Read ↗

⌁Select a neighboring publication to make it the new centre.