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Article

Oxidant regulated inter-subunit disulfide bond formation between ASIC1a subunits.

Proceedings of the National Academy of Sciences of the United States of America - 3 Mar 2009

Zha Xiang-ming, Wang Runping, Collier Dan M, Snyder Peter M, Wemmie John A, Welsh Michael J

Abstract excerpt

The acid-sensing ion channel-1a (ASIC1a) is composed of 3 subunits and is activated by a decrease in extracellular pH. It plays an important role in diseases associated with a reduced pH and production of oxidants. Previous work showed that oxidants reduce ASIC1a currents. However, the effects on...

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Identifiers

PMID: 19218436
DOI: 10.1073/pnas.0813402106
PMCID: PMC2642663

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 2 Sept 2026. Prepared record publication-19218436-2026-09-02.2. Manifest publication-graph-cohort-2026-09-02.2.

Source receipt: PubMed via Helena Literature Corpus, retrieved 2 Sept 2026.

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