Article

Mutation of a conserved Gln residue does not abolish desensitization of acid-sensing ion channel 1

2020-12-20

Abstract excerpt

Desensitization is a common feature of ligand-gated ion channels although the molecular cause varies widely between channel types. Mutations that substantially reduce or abolish desensitization have been described for many ligand-gated ion channels including glutamate, GABA, glycine and nicotinic receptors but not for acid-sensing ion channels (ASICs) until recently. Mutating Gln276 to a glycine in human ASIC1a wa...

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Literature Corpus work: 6d1db8eb-a129-5295-a79a-7cf40ec69f85
DOI: 10.1101/2020.12.19.423606

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