Article

Dynamic conformational changes of acid-sensing ion channels in different desensitizing conditions

2023-12-21

Abstract excerpt

Acid-sensing ion channels (ASICs) are proton-gated cation channels that contribute to fast synaptic transmission and have roles in fear conditioning and nociception. Apart from activation at low pH, ASIC1a also undergoes several types of desensitization, including ‘acute desensitization’ that terminates activation, ‘steady-stated desensitization’ that occurs at sub-activating proton concentrations and limits subse...

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Literature Corpus work: a8fcce79-cce1-5155-b49c-f9526045c667
DOI: 10.1101/2023.12.21.572759

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