Article
Molecular determinants of ASIC1 modulation by divalent cations.
Scientific reports - 28 Jan 2024
Liu Yi, Ma Jichun, DesJarlais Renee L, Hagan Rebecca, Rech Jason, Liu Changlu, Miller Robyn, Schoellerman Jeffrey, Luo Jinquan, Letavic Michael, Grasberger Bruce, Maher Michael P
Abstract excerpt
Acid-sensing ion channels (ASICs) are proton-gated cation channels widely expressed in the nervous system. ASIC gating is modulated by divalent cations as well as small molecules; however, the molecular determinants of gating modulation by divalent cations are not well understood. Previously, we identified two small molecules that bind to ASIC1a at a novel site in the acidic pocket and modulate ASIC1 gating in a...
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