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Article

Structural basis for amino acid exchange by a human heteromeric amino acid transporter

17 Aug 2020

Abstract excerpt

Significance Amino acids are involved in metabolism, protein biosynthesis, and signal transduction of humans. Heteromeric amino acid transporters maintain homeostasis of amino acid pools in various tissues and organs representing a unique group among members of the solute carrier superfamily. The neutral and basic amino acid transport complex (b [0,+] AT1-rBAT) is responsible for reabsorption of cystine and...

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PMID: 32817565
DOI: 10.1073/pnas.2008111117

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