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[Effects of midazolam on hERG K+ channel].

Zhongguo ying yong sheng li xue za zhi = Zhongguo yingyong shenglixue zazhi = Chinese journal of applied physiology - 1 Mar 2015

Han Sheng-na, Wang Pei, Zhang Wei, Zhang Li-rong

Abstract excerpt

OBJECTIVE: To investigate the effect of midazolam on human ether-a-go-go (hERG) K+ channels exogenously expressed in human embryonic kidney cells (HEK-293) and the underlying molecular mechanisms. METHODS: Whole-cell patch clamp technique was used to record WT, Y652A and F656C hERG K+ current expressed in HEK-293 cells. RESULTS: Midazolam inhibited hERG K+ current in a concentration-dependent manner, the...

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PMID: 26248421

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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