Article
Block of hERG channel by ziprasidone: biophysical properties and molecular determinants.
Biochemical pharmacology - 12 Jan 2006
Su Zhi, Chen Jun, Martin Ruth L, McDermott Jeffrey S, Cox Bryan F, Gopalakrishnan Murali, Gintant Gary A
Abstract excerpt
Ziprasidone, an antipsychotic agent, delays cardiac repolarization and, thus, prolongs the QT interval of the cardiac ECG. In this study, we examined the biophysical properties and the molecular determinants of the ziprasidone block of wild-type hERG potassium channels stably expressed in HEK-293 cells or wild-type and mutant hERG channels expressed in Xenopus oocytes. In stably transfected HEK-293 cells,...
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