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Article

Blockade of the human ether-a-go-go-related gene potassium channel by ketanserin.

Sheng li xue bao : [Acta physiologica Sinica] - 25 Aug 2008

Tu Dan-Na, Zou An-Ruo, Liao Yu-Hua, Du Yi-Mei, Wang Xian-Pei, Li Lu

Abstract excerpt

In the present study, we investigated the inhibitory action of ketanserin on wild-type (WT) and Y652 mutant human ether-a-go-go-related gene (HERG) potassium channels expressed in Xenopus oocytes and the effects of changing the channel molecular determinants characteristics on the blockade with a...

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PMID: 18690396

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 2 Sept 2026. Prepared record publication-18690396-2026-09-02.2. Manifest publication-graph-cohort-2026-09-02.2.

Source receipt: PubMed via Helena Literature Corpus, retrieved 2 Sept 2026.

Related research

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Blockade of the human ether-a-go-go-related gene potassium channel by ketanserin.PMID 18690396Read ↗

Blockade of the human ether-a-go-go-related gene potassium channel by ketamine.Semantic proximity Read ↗

Inhibition of the HERG K+ channel by the antifungal drug ketoconazole depends on channel gating and involves the S6 residue F656.Semantic proximity Read ↗

Block effect of capsaicin on hERG potassium currents is enhanced by S6 mutation at Y652.Semantic proximity Read ↗

Molecular Determinants for the High-Affinity Blockade of Human Ether-à-go-go-Related Gene K + Channel by Tolterodine.Semantic proximity Read ↗

Pharmacological corrections of the mutant hERG channels by posaconazole.Semantic proximity Read ↗

Translational toxicology and rescue strategies of the hERG channel dysfunction: biochemical and molecular mechanistic aspects.Semantic proximity Read ↗

A single amino acid difference between ether-a-go-go- related gene channel subtypes determines differential sensitivity to a small molecule activator.Semantic proximity Read ↗

Propofol inhibits hERG K+ channels and enhances the inhibition effects on its mutations in HEK293 cells.Semantic proximity Read ↗

Human ether-a-go-go related gene (hERG) K+ channels: function and dysfunction.Semantic proximity Read ↗

Clenbuterol Attenuates hERG Channel by Promoting the Mature Channel Degradation.Semantic proximity Read ↗

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Papaverine, a vasodilator, blocks the pore of the HERG channel at submicromolar concentration.Semantic proximity Read ↗

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