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Article

Pharmacological corrections of the mutant hERG channels by posaconazole.

Clinical and experimental pharmacology & physiology - 1 Jun 2021

Luo Chaodi, Zheng Xinglong, Li Jing, Zhang Yongjian, Shi Tao, Yan Yang, Han Dan

Abstract excerpt

Properties of mutant human ether-à-go-go-related gene (hERG) channels can be modified by some antibiotics. However, the pharmacological effects of posaconazole on cardiomyocyte hERG channels remain unclear. Whole-cell patch clamping, western blotting and laser confocal scanning microscopy were used to evaluate the effects of posaconazole on wild-type (WT)-, A561V- and L539 fs/47-hERG channels expressed in human...

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PMID: 33631842
DOI: 10.1111/1440-1681.13475

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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