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Article

Blockade of HERG K+ channel by an antihistamine drug brompheniramine requires the channel binding within the S6 residue Y652 and F656.

Journal of applied toxicology : JAT - 1 Mar 2008

Park Sang-Joon, Kim Ki-Suk, Kim Eun-Joo

Abstract excerpt

A number of clinically used drugs block delayed rectifier K+ channels and prolong the duration of cardiac action potentials associated with long QT syndrome. This study investigated the molecular mechanisms of voltage-dependent inhibition of human ether-a-go-go-related gene (HERG) delayed rectifier K+ channels expressed in HEK-293 cells by brompheniramine, an antihistamine. Brompheniramine inhibited HERG current...

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Identifiers

PMID: 17516459
DOI: 10.1002/jat.1252

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Related research

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Research trail→

Click a neighbor to travelStep 1 · 12 closest

Blockade of HERG K+ channel by an antihistamine drug brompheniramine requires the channel binding within the S6 residue Y652 and F656.PMID 17516459Read ↗

H(1) antihistamine drug promethazine directly blocks hERG K(+) channel.Semantic proximity Read ↗

Propofol inhibits hERG K+ channels and enhances the inhibition effects on its mutations in HEK293 cells.Semantic proximity Read ↗

Block of hERG channel by ziprasidone: biophysical properties and molecular determinants.Semantic proximity Read ↗

Clenbuterol Attenuates hERG Channel by Promoting the Mature Channel Degradation.Semantic proximity Read ↗

Human ether-a-go-go related gene (hERG) K+ channels: function and dysfunction.Semantic proximity Read ↗

[HERG K+ channel, the target of anti-arrhythmias drugs].Semantic proximity Read ↗

A common antitussive drug, clobutinol, precipitates the long QT syndrome 2.Semantic proximity Read ↗

Anticholinergic antiparkinson drug orphenadrine inhibits HERG channels: block attenuation by mutations of the pore residues Y652 or F656.Semantic proximity Read ↗

Blockade of HERG potassium currents by fluvoxamine: incomplete attenuation by S6 mutations at F656 or Y652.Semantic proximity Read ↗

Blockade of the human ether-a-go-go-related gene potassium channel by ketamine.Semantic proximity Read ↗

Block of the human ether-a-go-go-related gene (hERG) K+ channel by the antidepressant desipramine.Semantic proximity Read ↗

Lidoflazine is a high affinity blocker of the HERG K(+)channel.Semantic proximity Read ↗

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