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Article

Lidoflazine is a high affinity blocker of the HERG K(+)channel.

Journal of molecular and cellular cardiology - 1 May 2004

Ridley John M, Dooley Philip C, Milnes James T, Witchel Harry J, Hancox Jules C

Abstract excerpt

Lidoflazine is an antianginal calcium channel blocker that carries a significant risk of QT interval prolongation and ventricular arrhythmia. We investigated whether or not lidoflazine inhibits current through the rapid delayed rectifier K(+) channel alpha subunit (encoded by HERG - human ether-a-go-go-related gene), since this channel has been widely linked to drug-induced QT-prolongation. Lidoflazine inhibited...

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Source

Identifiers

PMID: 15135665
DOI: 10.1016/j.yjmcc.2004.02.009

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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Lidoflazine is a high affinity blocker of the HERG K(+)channel.PMID 15135665Read ↗

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