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Article

Molecular Determinants for the High-Affinity Blockade of Human Ether-à-go-go-Related Gene K + Channel by Tolterodine.

Journal of cardiovascular pharmacology - 1 Nov 2022

Wang Na, Yang Yang, Wen Jing, Fan Xin-Rong, Li Jian, Xiong Bing, Zhang Jin, Zeng Bo, Shen Jian-Wu, Chen Gui-Lan

Abstract excerpt

ABSTRACT: Tolterodine is a first-line antimuscarinic drug used to treat overactive bladder. Adverse cardiac effects including tachycardia and palpitations have been observed, presumably because of its inhibition of the human ether-à-go-go-related gene (hERG) K + channel. However, the molecular mechanism of hERG channel inhibition by tolterodine is largely unclear. In this study, we performed molecular docking to...

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Identifiers

PMID: 35881423
DOI: 10.1097/FJC.0000000000001336

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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