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Article

[Functional impact of hERG: from physiological role to target of anticancer therapy].

Vnitrni lekarstvi - 1 Jan 2000

Šatková Júlia, Bébarová Markéta

Abstract excerpt

The human ether-à-go-go related gene (hERG; officially designated as KCNH2) encodes the structure of protein forming α-subunit of voltage-gated ion channel which conducts the rapid component of delayed rectifier K+ current (IKr). This current plays an important role namely in the cardiac repolarization. Mutations in hERG result in inherited arrhythmogenic syndromes characterized by a lenghtening or shortening of...

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Source

Identifiers

PMID: 28334543

Genes

KCNH2

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

Related research

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Research trail→

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[Functional impact of hERG: from physiological role to target of anticancer therapy].PMID 28334543Read ↗

Human ether-a-go-go related gene (hERG) K+ channels: function and dysfunction.Semantic proximity Read ↗

HERG channel and cancer: A mechanistic review of carcinogenic processes and therapeutic potential.Semantic proximity Read ↗

hERG K(+) channels: structure, function, and clinical significance.Semantic proximity Read ↗

Translational toxicology and rescue strategies of the hERG channel dysfunction: biochemical and molecular mechanistic aspects.Semantic proximity Read ↗

A novel mutation in KCNH2 yields loss-of-function of hERG potassium channel in long QT syndrome 2.Semantic proximity Read ↗

[HERG K+ channel, the target of anti-arrhythmias drugs].Semantic proximity Read ↗

A novel missense mutation causing a G487R substitution in the S2-S3 loop of human ether-à-go-go-related gene channel.Semantic proximity Read ↗

HERG, a human inward rectifier in the voltage-gated potassium channel family.Semantic proximity Read ↗

Long QT syndrome: cellular basis and arrhythmia mechanism in LQT2.Semantic proximity Read ↗

Aborted Cardiac Arrest in LQT2 Related to Novel KCNH2 (hERG) Variant Identified in One Lithuanian Family.Semantic proximity Read ↗

Eag1 K+ Channel: Endogenous Regulation and Functions in Nervous System.Semantic proximity Read ↗

The long QT syndrome: a clinical counterpart of hERG mutations.Semantic proximity Read ↗

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