Article
[Functional impact of hERG: from physiological role to target of anticancer therapy].
Vnitrni lekarstvi - 1 Jan 2000
Šatková Júlia, Bébarová Markéta
Abstract excerpt
The human ether-à-go-go related gene (hERG; officially designated as KCNH2) encodes the structure of protein forming α-subunit of voltage-gated ion channel which conducts the rapid component of delayed rectifier K+ current (IKr). This current plays an important role namely in the cardiac repolarization. Mutations in hERG result in inherited arrhythmogenic syndromes characterized by a lenghtening or shortening of...
Topics
- Animals
- Apoptosis
- Arrhythmias, Cardiac
- Cell Proliferation
- ERG1 Potassium Channel
- Humans
- Molecular Targeted Therapy
- Muscle Contraction
- Muscle, Smooth
- Mutation
- Neoplasms