Article
Assessment of p53 and ATM functionality in chronic lymphocytic leukemia by multiplex ligation-dependent probe amplification.
Cell death & disease - 6 Aug 2015
te Raa G D, Moerland P D, Leeksma A C, Derks I A, Yigittop H, Laddach N, Loden-van Straaten M, Navrkalova V, Trbusek M, Luijks D M, Zenz T, Skowronska A, Hoogendoorn M, Stankovic T, van Oers M H, Eldering E, Kater A P
Abstract excerpt
The ATM-p53 DNA-damage response (DDR) pathway has a crucial role in chemoresistance in CLL, as indicated by the adverse prognostic impact of genetic aberrations of TP53 and ATM. Identifying and distinguishing TP53 and ATM functional defects has become relevant as epigenetic and posttranscriptional dysregulation of the ATM/p53 axis is increasingly being recognized as the underlying cause of chemoresistance. Also,...
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