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Article

The role of ATM mutations and 11q deletions in disease progression in chronic lymphocytic leukemia.

Leukemia & lymphoma - 1 Jun 2014

Stankovic Tatjana, Skowronska Anna

Abstract excerpt

Abstract ATM gene alteration is a frequent event in pathogenesis of chronic lymphocytic leukemia (CLL) and occurs as monoallelic loss in the form of 11q23 deletion, with and without mutation in the remaining ATM allele. ATM is a principal DNA damage response gene and biallelic ATM alterations lead to ATM functional loss and chemoresistance. The introduction of new therapies, such as intensive chemoimmunotherapy...

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Methodology Data sources Editorial policy Privacy Delete account & data About Contact Helena Bioinformatics

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Source

Identifiers

PMID: 23906020
DOI: 10.3109/10428194.2013.829919

Genes

ATM
BCR

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

Related research

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Research trail→

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The role of ATM mutations and 11q deletions in disease progression in chronic lymphocytic leukemia.PMID 23906020Read ↗

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Somatic ATM Mutations Indicate a Pathogenic Role of ATM in B-Cell Chronic Lymphocytic LeukemiaSemantic proximity Read ↗

ATM aberrations in chronic lymphocytic leukemia: del(11q) rather than ATM mutations is an adverse-prognostic biomarker.Semantic proximity Read ↗

ATM mutations in B-cell chronic lymphocytic leukemia.Semantic proximity Read ↗

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Mutations in the ATM gene lead to impaired overall and treatment-free survival that is independent of IGVH mutation status in patients with B-CLL.Semantic proximity Read ↗

Mutation status of the residual ATM allele is an important determinant of the cellular response to chemotherapy and survival in patients with chronic lymphocytic leukemia containing an 11q deletion.Semantic proximity Read ↗

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