Article
Microarray analysis reveals that TP53- and ATM-mutant B-CLLs share a defect in activating proapoptotic responses after DNA damage but are distinguished by major differences in activating prosurvival responses.
Blood - 1 Jan 2004
Stankovic Tatjana, Hubank Mike, Cronin Debbie, Stewart Grant S, Fletcher Danielle, Bignell Colin R, Alvi Azra J, Austen Belinda, Weston Victoria J, Fegan Christopher, Byrd Philip J, Moss Paul A H, Taylor A Malcolm R
Abstract excerpt
The ATM/p53-dependent DNA damage response pathway plays an important role in the progression of lymphoid tumors. Inactivation of the ATM or TP53 gene is frequent in B-cell lymphocytic leukemia (B-CLL) and leads to aggressive disease. Although the ATM and p53 pathways overlap, they are not congruent, and it is unclear how the mechanism of tumor progression differs between ATM- and p53-deficient tumors. Using...
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