Article
Mutations in the ATM gene lead to impaired overall and treatment-free survival that is independent of IGVH mutation status in patients with B-CLL.
Blood - 1 Nov 2005
Austen Belinda, Powell Judith E, Alvi Azra, Edwards Ian, Hooper Laura, Starczynski Jane, Taylor A Malcolm R, Fegan Christopher, Moss Paul, Stankovic Tatjana
Abstract excerpt
The ataxia telangiectasia mutated (ATM) protein is the principal activator of the p53 protein in the response to DNA double-strand breaks. Mutations in the ATM gene have been previously found in B-cell chronic lymphocytic leukemias (B-CLLs) but their clinical significance is unknown. We analyzed 155 CLL tumors and found 12% with ATM mutations and 4% with TP53 mutations; 2 tumors contained mutations in both genes....
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