Functional analysis of the ATM-p53-p21 pathway in the LRF CLL4 trial: blockade at the level of p21 is associated with short response duration.

doi:10.1158/1078-0432.CCR-11-2936

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Article

Functional analysis of the ATM-p53-p21 pathway in the LRF CLL4 trial: blockade at the level of p21 is associated with short response duration.

Clinical cancer research : an official journal of the American Association for Cancer Research - 1 Aug 2012

Lin Ke, Adamson Janet, Johnson Gillian G, Carter Anthony, Oates Melanie, Wade Rachel, Richards Sue, Gonzalez David, Matutes Estella, Dearden Claire, Oscier David G, Catovsky Daniel, Pettitt Andrew R

Abstract excerpt

PURPOSE: This study sought to establish whether functional analysis of the ATM-p53-p21 pathway adds to the information provided by currently available prognostic factors in patients with chronic lymphocytic leukemia (CLL) requiring frontline chemotherapy. EXPERIMENTAL DESIGN: Cryopreserved blood mononuclear cells from 278 patients entering the LRF CLL4 trial comparing chlorambucil, fludarabine, and fludarabine...

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PMID: 22675167
DOI: 10.1158/1078-0432.CCR-11-2936

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