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Article

Epigenetic profile in chronic lymphocytic leukemia using methylation-specific multiplex ligation-dependent probe amplification.

Epigenomics - 1 Oct 2012

Cosialls Ana M, Santidrián Antonio F, Coll-Mulet Llorenç, Iglesias-Serret Daniel, González-Gironès Diana M, Pérez-Perarnau Alba, Rubio-Patiño Camila, González-Barca Eva, Alonso Esther, Pons Gabriel, Gil Joan

Abstract excerpt

AIM: To analyze the methylation status of 35 tumor suppressor genes using methylation-specific multiplex ligation-dependent probe amplification (MS-MLPA) in chronic lymphocytic leukemia (CLL). MATERIALS & METHODS: The DNA of 37 samples from patients with CLL, six healthy donors, and Jurkat and Ramos cell lines was analyzed by MS-MLPA. RESULTS: Our results confirm that hypermethylation is a common and not randomly...

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Source

Identifiers

PMID: 23130831
DOI: 10.2217/epi.12.40

Genes

CDH13
DAPK1
GATA5
RARB

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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