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Article

ATM gene alterations in chronic lymphocytic leukemia patients induce a distinct gene expression profile and predict disease progression.

Haematologica - 1 Jan 2012

Guarini Anna, Marinelli Marilisa, Tavolaro Simona, Bellacchio Emanuele, Magliozzi Monia, Chiaretti Sabina, De Propris Maria Stefania, Peragine Nadia, Santangelo Simona, Paoloni Francesca, Nanni Mauro, Del Giudice Ilaria, Mauro Francesca Romana, Torrente Isabella, Foà Robin

Abstract excerpt

BACKGROUND: The genetic characterization of chronic lymphocytic leukemia cells correlates with the behavior, progression and response to treatment of the disease. DESIGN AND METHODS: Our aim was to investigate the role of ATM gene alterations, their biological consequences and their value in predicting disease progression. The ATM gene was analyzed by denaturing high performance liquid chromatography and...

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Share to Ataxia Telangiectasia Mutated Proteins
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Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Share to Gene Duplication

Share to Leukemia, Lymphocytic, Chronic, B-Cell

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Source

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Identifiers

PMID: 21993670
DOI: 10.3324/haematol.2011.049270
PMCID: PMC3248930

Genes

ATM

Provenance

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