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Article

Incidence and clinical implications of ATM aberrations in chronic lymphocytic leukemia.

Genes, chromosomes & cancer - 1 Dec 2012

Ouillette Peter, Li Jinghui, Shaknovich Rita, Li Yifeng, Melnick Ari, Shedden Kerby, Malek Sami N

Abstract excerpt

A subset of chronic lymphocytic leukemia (CLL) carries mutations in ataxia telangiectasia mutated (ATM). Such ATM mutations may be particularly relevant in the setting of del11q, which invariably results in the deletion of one ATM allele. To improve our understanding of the frequency and type of...

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Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Share to Chromosome Deletion

Share to Chromosomes, Human, Pair 11

Share to Leukemia, Lymphocytic, Chronic, B-Cell

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Source

Open in PubMed Open full text

Identifiers

PMID: 22952040
DOI: 10.1002/gcc.21997
PMCID: PMC3465492

Genes

ATM

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 4 Sept 2026. Prepared record publication-22952040-2026-09-04.2. Manifest publication-graph-cohort-2026-09-04.2.

Source receipt: PubMed via Helena Literature Corpus, retrieved 4 Sept 2026.

Related research

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Research trail→

Click a neighbor to travelStep 1 · 12 closest

Incidence and clinical implications of ATM aberrations in chronic lymphocytic leukemia.PMID 22952040Read ↗

The role of ATM mutations and 11q deletions in disease progression in chronic lymphocytic leukemia.Semantic proximity Read ↗

Rare Germline ATM Variants Influence the Development of Chronic Lymphocytic Leukemia.Semantic proximity Read ↗

Biallelic ATM inactivation significantly reduces survival in patients treated on the United Kingdom Leukemia Research Fund Chronic Lymphocytic Leukemia 4 trial.Semantic proximity Read ↗

ATM gene alterations in chronic lymphocytic leukemia patients induce a distinct gene expression profile and predict disease progression.Semantic proximity Read ↗

ATM aberrations in chronic lymphocytic leukemia: del(11q) rather than ATM mutations is an adverse-prognostic biomarker.Semantic proximity Read ↗

ATM mutations in B-cell chronic lymphocytic leukemia.Semantic proximity Read ↗

Somatic ATM Mutations Indicate a Pathogenic Role of ATM in B-Cell Chronic Lymphocytic LeukemiaSemantic proximity Read ↗

Prognostic significance of ATM mutations in chronic lymphocytic leukemia: A meta-analysis.Semantic proximity Read ↗

Mutations in the ATM gene lead to impaired overall and treatment-free survival that is independent of IGVH mutation status in patients with B-CLL.Semantic proximity Read ↗

Somatic ATM mutations indicate a pathogenic role of ATM in B-cell chronic lymphocytic leukemia.Semantic proximity Read ↗

ATM germline heterozygosity does not play a role in chronic lymphocytic leukemia initiation but influences rapid disease progression through loss of the remaining ATM allele.Semantic proximity Read ↗

ATM mutations are rare in familial chronic lymphocytic leukemia.Semantic proximity Read ↗

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