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Article

Present status and perspectives in functional analysis of p53 in chronic lymphocytic leukemia.

Leukemia & lymphoma - 1 Aug 2012

de Viron Emeline, Michaux Lucienne, Put Natalie, Bontemps Françoise, Van Den Neste Eric

Abstract excerpt

Aberrations of TP53 (mutations and/or deletions) are associated with a dismal prognosis in chronic lymphocytic leukemia (CLL). Complete loss of ATM is another mechanism of failed DNA damage response and also associated with poorer prognosis in CLL. However, p53 dysfunction may arise through alternative mechanisms unrelated to structural aberrations (deletion and/or mutation) of TP53 or ATM, and thus be...

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Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

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Share to In Situ Hybridization, Fluorescence

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Share to Leukemia, Lymphocytic, Chronic, B-Cell

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Identifiers

PMID: 22280536
DOI: 10.3109/10428194.2012.660630

Genes

ATM

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