Biallelic ATM inactivation significantly reduces survival in patients treated on the United Kingdom Leukemia Research Fund Chronic Lymphocytic Leukemia 4 trial.

doi:10.1200/JCO.2011.41.0852

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Biallelic ATM inactivation significantly reduces survival in patients treated on the United Kingdom Leukemia Research Fund Chronic Lymphocytic Leukemia 4 trial.

Journal of clinical oncology : official journal of the American Society of Clinical Oncology - 20 Dec 2012

Skowronska Anna, Parker Anton, Ahmed Gulshanara, Oldreive Ceri, Davis Zadie, Richards Sue, Dyer Martin, Matutes Estella, Gonzalez David, Taylor A Malcolm R, Moss Paul, Thomas Peter, Oscier David, Stankovic Tatjana

Abstract excerpt

PURPOSE: The prognostic significance of ATM mutations in chronic lymphocytic leukemia (CLL) is unclear. We assessed their impact in the context of a prospective randomized trial. PATIENTS AND METHODS: We analyzed the ATM gene in 224 patients treated on the Leukemia Research Fund Chronic Lymphocytic Leukemia 4 (LRF-CLL4) trial with chlorambucil or fludarabine with and without cyclophosphamide. ATM status was...

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PMID: 23091097
DOI: 10.1200/JCO.2011.41.0852

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Biallelic ATM inactivation significantly reduces survival in patients treated on the United Kingdom Leukemia Research Fund Chronic Lymphocytic Leukemia 4 trial.PMID 23091097Read ↗

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