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Targeting ATM-deficient CLL through interference with DNA repair pathways

10 Jun 2015

Abstract excerpt

Chronic lymphocytic leukemia (CLL) is the most common form of leukemia in the Western world and accounts for approximately 30% of adult leukemias and 25% of non-Hodgkin lymphomas. The median age at diagnosis is 72 years. During recent years numerous genetic aberrations have been identified that are associated with an aggressive course of the disease and resistance against genotoxic chemotherapies. The DNA...

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PMID: 26113859
DOI: 10.3389/fgene.2015.00207

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