Article
Evaluation of predictive CYP2C19 genotyping assays relative to measured phenotype in a South African cohort.
Pharmacogenomics - 1 Jan 2015
Dodgen Tyren M, Drögemöller Britt I, Wright Galen E B, Warnich Louise, Steffens Francois E, Cromarty A Duncan, Alessandrini Marco, Pepper Michael S
Abstract excerpt
AIM: To align predicted and measured CYP2C19 phenotype in a South African cohort. MATERIALS & METHODS: Genotyping of CYP2C19*2, *3, *9, *15, *17, *27 and *28 was performed using PCR-RFLP, and an activity score (AS) system was used to predict phenotype. True phenotype was measured using plasma concentrations of omeprazole and its metabolite 5'-hydroxyomperazole. RESULTS: Partial genotype-phenotype discrepancies...
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