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Article

Challenges in CYP2D6 phenotype assignment from genotype data: a critical assessment and call for standardization.

Current drug metabolism - 1 Feb 2014

Hicks J Kevin, Swen Jesse J, Gaedigk Andrea

Abstract excerpt

The cytochrome P450 2D6 (CYP2D6) enzyme contributes to the metabolism and/or bioactivation of approximately 25% of clinically used drugs. The CYP2D6 gene locus is highly polymorphic and complex, and variants within this gene locus affect CYP2D6 enzymatic function resulting in a wide range of metabolic activity from little to no activity to ultrarapid metabolism. For many of the drugs metabolized by CYP2D6, the...

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Share to Cytochrome P-450 CYP2D6
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Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

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Source

Identifiers

PMID: 24524666
DOI: 10.2174/1389200215666140202215316

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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