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Article

The CYP2D6 activity score: translating genotype information into a qualitative measure of phenotype.

Clinical pharmacology and therapeutics - 1 Feb 2008

Gaedigk A, Simon S D, Pearce R E, Bradford L D, Kennedy M J, Leeder J S

Abstract excerpt

Inferring CYP2D6 phenotype from genotype is increasingly challenging, considering the growing number of alleles and their range of activity. This complexity poses a challenge in translational research where genotyping is being considered as a tool to personalize drug therapy. To simplify genotype interpretation and improve phenotype prediction, we evaluated the utility of an "activity score" (AS) system. Over 25...

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PMID: 17971818
DOI: 10.1038/sj.clpt.6100406

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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