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Article

Prediction of CYP2D6 phenotype from genotype across world populations.

Genetics in medicine : official journal of the American College of Medical Genetics - 1 Jan 2017

Gaedigk Andrea, Sangkuhl Katrin, Whirl-Carrillo Michelle, Klein Teri, Leeder J Steven

Abstract excerpt

PURPOSE: Owing to its highly polymorphic nature and major contribution to the metabolism and bioactivation of numerous clinically used drugs, CYP2D6 is one of the most extensively studied drug-metabolizing enzymes and pharmacogenes. CYP2D6 alleles confer no, decreased, normal, or increased activity and cause a wide range of activity among individuals and between populations. However, there is no standard approach...

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Cytochrome P-450 CYP2D6
Ethnicity
Gene Frequency
Genetics, Population
Genotype

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Inactivation, Metabolic

Pharmacogenetics

Polymorphism, Genetic

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Open in PubMed Open full text

Identifiers

PMID: 27388693
DOI: 10.1038/gim.2016.80
PMCID: PMC5292679

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