Article
Determination of CYP2C19 phenotype in black Americans with omeprazole: correlation with genotype.
Clinical pharmacology and therapeutics - 1 Aug 1996
Marinac J S, Balian J D, Foxworth J W, Willsie S K, Daus J C, Owen R, Flockhart D A
Abstract excerpt
BACKGROUND: Our objective was to study omeprazole as a single-dose oral probe in the determination of CYP2C19 phenotype in black subjects and to determine the correlation between phenotype and genotype. METHODS: This single-dose, open-label outpatient study was conducted at a community-based, uni...
Topics
- 2-Pyridinylmethylsulfinylbenzimidazoles
- Adult
- Aryl Hydrocarbon Hydroxylases
- Black People
- Cytochrome P-450 CYP2C19
- Cytochrome P-450 Enzyme System
- Enzyme Inhibitors
- Female
- Genotype
- Humans
- Male
- Middle Aged
- Mixed Function Oxygenases
- Omeprazole
- Phenotype
- Reference Values
- Black or African American