Article
The effect of the CYP2C19 genotype on the hydroxylation index of omeprazole in South Indians.
European journal of clinical pharmacology - 1 Mar 2005
Rosemary J, Adithan C, Padmaja N, Shashindran C H, Gerard N, Krishnamoorthy R
Abstract excerpt
To investigate the relationship between CYP2C19 genotypes and the hydroxylation index (HI) of omeprazole in the South Indian population. Healthy unrelated South Indian subjects (n=300) were separated into three groups based on their CYP2C19 genotypes. They were administered a single oral dose of 20 mg omeprazole, and venous blood was collected 3 h later. Plasma was assayed using reversed-phase high-performance...
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