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Article

Intrinsic mutagenic properties of 5-chlorocytosine: A mechanistic connection between chronic inflammation and cancer.

Proceedings of the National Academy of Sciences of the United States of America - 18 Aug 2015

Fedeles Bogdan I, Freudenthal Bret D, Yau Emily, Singh Vipender, Chang Shiou-chi, Li Deyu, Delaney James C, Wilson Samuel H, Essigmann John M

Abstract excerpt

During chronic inflammation, neutrophil-secreted hypochlorous acid can damage nearby cells inducing the genomic accumulation of 5-chlorocytosine (5ClC), a known inflammation biomarker. Although 5ClC has been shown to promote epigenetic changes, it has been unknown heretofore if 5ClC directly perpetrates a mutagenic outcome within the cell. The present work shows that 5ClC is intrinsically mutagenic, both in vitro...

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Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

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Identifiers

PMID: 26243878
DOI: 10.1073/pnas.1507709112
PMCID: PMC4547254

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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