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Structurally Similar Mycotoxins Aflatoxin B1 and Sterigmatocystin Trigger Different and Distinctive High-Resolution Mutational Spectra in Mammalian Cells.

Toxins - 27 Feb 2025

Thongararm Pennapa, Chancharoen Marisa, Suwanwong Nutchapong, Ruchirawat Somsak, Ruchirawat Mathuros, Fedeles Bogdan I, Croy Robert G, Essigmann John M

Abstract excerpt

Aflatoxin B1 (AFB1) and sterigmatocystin (ST) are mycotoxins that pose significant threats to human and animal health owing to their mutagenic, carcinogenic, and toxic properties. They are structurally similar and widely believed to exert their biological effects via the generation of DNA-damaging epoxides at their respective terminal furan rings. Despite structural identity in the warhead portion of each toxin,...

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PMID: 40137885
DOI: 10.3390/toxins17030112
PMCID: PMC11945433

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