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Article

Mutagenic potential of hypoxanthine in live human cells.

Mutation research - 1 Oct 2017

DeVito Stephen, Woodrick Jordan, Song Linze, Roy Rabindra

Abstract excerpt

Hypoxanthine (Hx) is a major DNA lesion generated by deamination of adenine during chronic inflammatory conditions, which is an underlying cause of various diseases including cancer of colon, liver, pancreas, bladder and stomach. There is evidence that deamination of DNA bases induces mutations, but no study has directly linked Hx accumulation to mutagenesis and strand-specific mutations yet in human cells. Using...

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Identifiers

PMID: 28704682
DOI: 10.1016/j.mrfmmm.2017.06.005
PMCID: PMC5623627

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