Article

The proinflammatory response induced by the Cytolethal Distending Toxin depends on cGAS

2021-02-16

Abstract excerpt

<title>Abstract</title> <p>The Cytolethal Distending Toxin (CDT) is a bacterial genotoxin produced by pathogenic bacteria causing major foodborne diseases worldwide. CDT activates the DNA damage response and induces inflammatory signatures in host cells, but the precise relationship between these outcomes has not been addressed so far. Here, we show that the cellular proinflammatory response and senescence induce...

Topics

Open a Topic to create a Post that cites this publication.

Identifiers and source

Literature Corpus work: 86265b54-5324-52a6-8384-036ebc5a6a4e
DOI: 10.21203/rs.3.rs-162979/v1

Open publication

Related research

Semantic proximity does not establish scientific evidence.

Click a neighbor to travelStep 1 · 12 closest

The proinflammatory response induced by the Cytolethal Distending Toxin depends on cGASDOI 10.21203/rs.3.rs-162979/v1Read

Chronic exposure to Cytolethal Distending Toxin (CDT) promotes a cGAS-dependent type I interferon responseSemantic proximity Read

Bacterial genotoxins induce T cell senescenceSemantic proximity Read

Cytolethal Distending Toxin: A Bacterial Bullet Targeted to NucleusSemantic proximity Read

Mitochondrial injury induced by a Salmonella genotoxin triggers the proinflammatory senescence-associated secretory phenotype.Semantic proximity Read

The multifaceted functions of cGASSemantic proximity Read

Bacterial intoxication evokes cellular senescence with persistent DNA damage and cytokine signalling.Semantic proximity Read

The Haemophilus ducreyi cytolethal distending toxin induces cell cycle arrest and apoptosis via the DNA damage checkpoint pathways.Semantic proximity Read

The crosstalk between DNA-damage responses and innate immunitySemantic proximity Read

cGAS‐STING signaling in cell death: Mechanisms of action and implications in pathologiesSemantic proximity Read

Replication Stress, DNA Damage, Inflammatory Cytokines and Innate Immune ResponseSemantic proximity Read

Escherichia coli Producing Colibactin Triggers Premature and Transmissible Senescence in Mammalian CellsSemantic proximity Read

Genotoxicity of Cytolethal Distending Toxin (CDT) on Isogenic Human Colorectal Cell Lines: Potential Promoting Effects for Colorectal CarcinogenesisSemantic proximity Read