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Article

The Crohn's disease-associated polymorphism in ATG16L1 (rs2241880) reduces SHIP gene expression and activity in human subjects.

Genes and immunity - 1 Oct 2015

Ngoh E N, Brugger H K, Monajemi M, Menzies S C, Hirschfeld A F, Del Bel K L, Jacobson K, Lavoie P M, Turvey S E, Sly L M

Abstract excerpt

Crohn's disease (CD) is a polygenic immune-mediated disease characterized by gastrointestinal inflammation. Mice deficient in the hematopoietic-restricted SH2 domain-containing inositolpolyphosphate 5'-phosphatase (SHIP) develop spontaneous CD-like ileal inflammation. Intriguingly, SHIP mRNA is not upregulated in biopsies from patients with ileal CD despite immune cell infiltration, but SHIP's role in human CD...

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PMID: 26226011
DOI: 10.1038/gene.2015.30

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

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