Article
Crohn's disease-associated ATG16L1 T300A genotype is associated with improved survival in gastric cancer.
EBioMedicine - 1 May 2021
Ma Changqing, Storer Chad E, Chandran Uma, LaFramboise William A, Petrosko Patricia, Frank Madison, Hartman Douglas J, Pantanowitz Liron, Haritunians Talin, Head Richard D, Liu Ta-Chiang
Abstract excerpt
BACKGROUND: A non-synonymous single nucleotide polymorphism of the ATG16L1 gene, T300A, is a major Crohn's disease (CD) susceptibility allele, and is known to be associated with increased apoptosis induction in the small intestinal crypt base in CD subjects and mouse models. We hypothesized that ATG16L1 T300A genotype also correlates with increased tumor apoptosis and therefore could lead to superior clinical...
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