A genome-wide association scan of nonsynonymous SNPs identifies a susceptibility variant for Crohn disease in ATG16L1.

doi:10.1038/ng1954

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Article

A genome-wide association scan of nonsynonymous SNPs identifies a susceptibility variant for Crohn disease in ATG16L1.

Nature genetics - 1 Feb 2007

Hampe Jochen, Franke Andre, Rosenstiel Philip, Till Andreas, Teuber Markus, Huse Klaus, Albrecht Mario, Mayr Gabriele, De La Vega Francisco M, Briggs Jason, Günther Simone, Prescott Natalie J, Onnie Clive M, Häsler Robert, Sipos Bence, Fölsch Ulrich R, Lengauer Thomas, Platzer Matthias, Mathew Christopher G, Krawczak Michael, Schreiber Stefan

Abstract excerpt

We performed a genome-wide association study of 19,779 nonsynonymous SNPs in 735 individuals with Crohn disease and 368 controls. A total of 7,159 of these SNPs were informative. We followed up on all 72 SNPs with P <or= 0.01 with an allele-based disease association test in 380 independent Crohn disease trios, 498 Crohn disease singleton cases and 1,032 controls. Disease association of rs2241880 in the...

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PMID: 17200669
DOI: 10.1038/ng1954

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

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