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Genome-wide Association Scanning Highlights Two Autophagy Genes,<i>ATG16L1</i>and<i>IRGM</i>, as Being Significantly Associated with Crohn’s Disease

26 Nov 2007

Abstract excerpt

The era of genome-wide association (GWA) scanning has shed new light on the genetic basis of common disease and nowhere is this better illustrated than Crohn’s disease (CD). CD is a chronic debilitating inflammatory bowel disease characterized by stricturing and fistula formation. Mainstays of current therapy are immune suppression and surgery. The pathogenesis of CD is poorly understood, but it has long been...

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PMID: 17921695
DOI: 10.4161/auto.5075

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