Article
SHIP1 Deficiency in Inflammatory Bowel Disease Is Associated With Severe Crohn's Disease and Peripheral T Cell Reduction.
Frontiers in immunology - 1 Jan 2018
Fernandes Sandra, Srivastava Neetu, Sudan Raki, Middleton Frank A, Shergill Amandeep K, Ryan James C, Kerr William G
Abstract excerpt
In our previous study, we observed a severe reduction in the Src homology 2-containing-inositol-phosphatase-1 (SHIP1) protein in a subpopulation of subjects from a small adult Crohn's Disease (CD) cohort. This pilot study had been undertaken since we had previously demonstrated that engineered deficiency of SHIP1 in mice results in a spontaneous and severe CD-like ileitis. Here, we extend our analysis of SHIP1...
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