Article
Phenotype-genotype profiles in Crohn's disease predicted by genetic markers in autophagy-related genes (GOIA study II).
Inflammatory bowel diseases - 1 Feb 2013
Durães Cecília, Machado José C, Portela Francisco, Rodrigues Susana, Lago Paula, Cravo Marília, Ministro Paula, Marques Margarida, Cremers Isabelle, Freitas João, Cotter José, Tavares Lurdes, Matos Leopoldo, Medeiros Isabel, Sousa Rui, Ramos Jaime, Deus João, Caldeira Paulo, Chagas Cristina, Duarte Maria A, Gonçalves Raquel, Loureiro Rui, Barros Luísa, Bastos Isabel, Cancela Eugénia, Moraes Mário C, Moreira Maria J, Vieira Ana I, Magro Fernando
Abstract excerpt
BACKGROUND: About 70 loci are associated with susceptibility to Crohn's disease (CD), particularly in pathways of innate immunity, autophagy, and pathogen recognition. Phenotype-genotype associations are inconsistent. METHODS: CD susceptibility polymorphisms ATG16L1 rs2241880, ICAM1 rs5498, IL4 rs2070874, IL17F rs763780, IRGM , ITLN1 , LRRK2 , and TLR4 were genotyped in a...