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Article

Genetic association and functional role of Crohn disease risk alleles involved in microbial sensing, autophagy, and endoplasmic reticulum (ER) stress.

Autophagy - 1 Dec 2013

Hoefkens Eveline, Nys Kris, John Jestinah M, Van Steen Kristel, Arijs Ingrid, Van der Goten Jan, Van Assche Gert, Agostinis Patrizia, Rutgeerts Paul, Vermeire Séverine, Cleynen Isabelle

Abstract excerpt

Genome-wide association studies have identified several genes implicated in autophagy (ATG16L1, IRGM, ULK1, LRRK2, and MTMR3), intracellular bacterial sensing (NOD2), and endoplasmic reticulum (ER) stress (XBP1 and ORMDL3) to be associated with Crohn disease (CD). We studied the known CD-associated variants in these genes in a large cohort of 3451 individuals (1744 CD patients, 793 ulcerative colitis (UC)...

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Source

Identifiers

PMID: 24247223
DOI: 10.4161/auto.26337

Genes

IRGM
MTMR3
NOD2
ORMDL3
ULK1
XBP1

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 6 Sept 2026. Manifest publication-graph-cohort-2026-09-06.1.

Source receipt: pubmed, retrieved 6 Sept 2026.

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