Article
Analysis of SHIP1 expression and activity in Crohn's disease patients.
PloS one - 1 Jan 2017
Somasundaram Rajesh, Fernandes Sandra, Deuring Jasper J, de Haar Colin, Kuipers Ernst J, Vogelaar Lauran, Middleton Frank A, van der Woude C Janneke, Peppelenbosch Maikel P, Kerr William G, Fuhler Gwenny M
Abstract excerpt
BACKGROUND: SH2 domain containing inositol-5-phosphatase (SHIP1) is an important modulator of innate and adaptive immunity. In mice, loss of SHIP1 provokes severe ileitis resembling Crohn's disease (CD), as a result of deregulated immune responses, altered cytokine production and intestinal fibrosis. Recently, SHIP1 activity was shown to be correlated to the presence of a CD-associated single nucleotide...
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