Loading publication...

Noodle always counts identifier-free feature events for service operation. With your permission, Google Analytics can also estimate audience and engagement. Search text, publication identifiers, cookies, IP addresses and browser fingerprints are never included in Noodle's first-party event counters.

Privacy details

Article

Autophagy and Crohn's disease.

Journal of innate immunity - 1 Jan 2013

Nguyen Hang Thi Thu, Lapaquette Pierre, Bringer Marie-Agnès, Darfeuille-Michaud Arlette

Abstract excerpt

Advances in genetics have shed light on the molecular basis of Crohn's disease (CD) predisposition and pathogenesis, via linkage disequilibrium analysis to genome-wide association studies. The discovery of genetic variants of NOD2, an intracellular pathogen molecular sensor, as risk factors for CD has paved the way for further research on innate immunity in this disease. Remarkably, polymorphisms in autophagy...

Topics

Join the communities discussing this publication.

Autophagy
Autophagy-Related Proteins
Carrier Proteins
Crohn Disease
Genome-Wide Association Study

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

GTP-Binding Proteins

Immunity, Innate

Nod2 Signaling Adaptor Protein

Source

Open in PubMed Open full text

Identifiers

PMID: 23328432
DOI: 10.1159/000345129
PMCID: PMC6741541

Genes

IRGM
NOD2

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 1 Sept 2026.

Community interpretation

Discuss the evidence

Ask a question, add context or challenge an interpretation. Community activity is separate from scientific evidence strength.

0

discussions

0

replies

Citations encouraged

Claims remain attributable.

No discussion yet

Be the first to add a careful, cited interpretation.

Related research

Semantic proximity does not establish scientific evidence.

Research trail→

Click a neighbor to travelStep 1 · 12 closest

Autophagy and Crohn's disease.PMID 23328432Read ↗

Innate immune defence: NOD2 and autophagy in the pathogenesis of Crohn's disease.Semantic proximity Read ↗

Crohn's disease: NOD2, autophagy and ER stress converge.Semantic proximity Read ↗

Functional consequences of mutations in the autophagy genes in the pathogenesis of Crohn's disease.Semantic proximity Read ↗

ATG16L1 and NOD2 interact in an autophagy-dependent antibacterial pathway implicated in Crohn's disease pathogenesis.Semantic proximity Read ↗

Role of autophagy and autophagy genes in inflammatory bowel disease.Semantic proximity Read ↗

Autophagy and Crohns Disease: At the Crossroads of Infection, Inflammation, Immunity, and CancerSemantic proximity Read ↗

ATG16L1 polymorphisms are associated with NOD2-induced hyperinflammation.Semantic proximity Read ↗

Bacterial invasion: linking autophagy and innate immunity.Semantic proximity Read ↗

The complex interplay of NOD-like receptors and the autophagy machinery in the pathophysiology of Crohn disease.Semantic proximity Read ↗

Alterations of autophagic and innate immune responses by the Crohn's disease-associated ATG16L1 mutation.Semantic proximity Read ↗

Inflammatory bowel disease: dysfunction of autophagy?Semantic proximity Read ↗

Evidence from genetics for a role of autophagy and innate immunity in IBD pathogenesis.Semantic proximity Read ↗

⌁Select a neighboring publication to make it the new centre.