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ATG16L1: A multifunctional susceptibility factor in Crohn disease.

Autophagy - 3 Apr 2015

Salem Mohammad, Ammitzboell Mette, Nys Kris, Seidelin Jakob Benedict, Nielsen Ole Haagen

Abstract excerpt

Genetic variations in the autophagic pathway influence genetic predispositions to Crohn disease. Autophagy, the major lysosomal pathway for degrading and recycling cytoplasmic material, constitutes an important homeostatic cellular process. Of interest, single-nucleotide polymorphisms in ATG16L1 (autophagy-related 16-like 1 [S. cerevisiae]), a key component in the autophagic response to invading pathogens, have...

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Identifiers

PMID: 25906181
DOI: 10.1080/15548627.2015.1017187
PMCID: PMC4502774

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