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Crohn’s disease IRGM risk alleles are associated with altered gene expression in human tissues

18 Oct 2018

Abstract excerpt

Crohn's disease (CD) is a chronic inflammatory gastrointestinal disorder. Genetic association studies have implicated dysregulated autophagy in CD. Among risk loci identified are a promoter single nucleotide polymorphism (SNP)( rs13361189 ) and two intragenic SNPs ( rs9637876 , rs10065172 ) in immunity-related GTPase family M ( IRGM) a gene that encodes a protein of the autophagy initiation complex. All three...

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PMID: 30335469
DOI: 10.1152/ajpgi.00196.2018

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Crohn’s disease IRGM risk alleles are associated with altered gene expression in human tissuesPMID 30335469Read ↗

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