Article
Very long haplotype tracts characterized at high resolution from HLA homozygous cell lines.
Immunogenetics - 1 Sept 2015
Norman Paul J, Norberg Steve J, Nemat-Gorgani Neda, Royce Thomas, Hollenbach Jill A, Shults Won Melissa, Guethlein Lisbeth A, Gunderson Kevin L, Ronaghi Mostafa, Parham Peter
Abstract excerpt
The HLA region of chromosome 6 contains the most polymorphic genes in humans. Spanning ~5 Mbp the densely packed region encompasses approximately 175 expressed genes including the highly polymorphic HLA class I and II loci. Most of the other genes and functional elements are also polymorphic, and many of them are directly implicated in immune function or immune-related disease. For these reasons, this complex...
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