Long-range multilocus haplotype phasing of the MHC.

doi:10.1073/pnas.0602286103

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Article

Long-range multilocus haplotype phasing of the MHC.

Proceedings of the National Academy of Sciences of the United States of America - 2 May 2006

Guo Zhen, Hood Leroy, Malkki Mari, Petersdorf Effie W

Abstract excerpt

Haplotypes are a powerful tool for identifying the genetic basis of common complex diseases. Disease-association mapping requires molecular methods for haplotyping biallelic SNP variation and highly complex polymorphisms. We developed a method for phasing HLA-A, HLA-B, and HLA-DRB1 alleles on chromosome 6 in unrelated individuals. This method uses the highly polymorphic HLA-B locus to discriminate the two HLA...

Topics

Genes, MHC Class I
Genes, MHC Class II
Genetic Predisposition to Disease
Genetic Variation
HLA Antigens
Haplotypes
Humans
Major Histocompatibility Complex
Oligonucleotide Array Sequence Analysis

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Identifiers

PMID: 16632595
DOI: 10.1073/pnas.0602286103
PMCID: PMC1459002

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