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Article

Complete haplotype phasing of the MHC and KIR loci with targeted HaploSeq.

BMC genomics - 5 Nov 2015

Selvaraj Siddarth, Schmitt Anthony D, Dixon Jesse R, Ren Bing

Abstract excerpt

BACKGROUND: The MHC and KIR loci are clinically relevant regions of the genome. Typing the sequence of these loci has a wide range of applications including organ transplantation, drug discovery, pharmacogenomics and furthering fundamental research in immune genetics. Rapid advances in biochemical and next-generation sequencing (NGS) technologies have enabled several strategies for precise genotyping and phasing...

Topics

Genotype
Haplotypes
High-Throughput Nucleotide Sequencing
Humans
Major Histocompatibility Complex
Receptors, KIR

Source

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Identifiers

PMID: 26541200
DOI: 10.1186/s12864-015-1949-7
PMCID: PMC4636068

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