Article
Complete haplotype phasing of the MHC and KIR loci with targeted HaploSeq.
BMC genomics - 5 Nov 2015
Selvaraj Siddarth, Schmitt Anthony D, Dixon Jesse R, Ren Bing
Abstract excerpt
BACKGROUND: The MHC and KIR loci are clinically relevant regions of the genome. Typing the sequence of these loci has a wide range of applications including organ transplantation, drug discovery, pharmacogenomics and furthering fundamental research in immune genetics. Rapid advances in biochemical and next-generation sequencing (NGS) technologies have enabled several strategies for precise genotyping and phasing...
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